Jeffrey Bender

Bio Profile

Jeffrey R. Bender, MD

Robert I. Levy Professor of Medicine (Cardiology) and Professor of Immunobiology

Associate Chief, Cardiovascular Medicine

Director, Yale Cardiovascular Research Center

Research Interests

Cardiology; Endothelium; Immune System; Inflammation; Macrophages; RNA Stability; T-Lymphocytes

Clinical Interests

Cardiovascular Diseases

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Bender Lab


My laboratory has had a longstanding interest in inflammation and immunity, as they relate to vascular physiology and pathology. The interactions between mononuclear leukocytes and endothelial cells play major roles in atherogenesis, acute and chronic manifestations of atherosclerosis, angiogenesis and allograft rejection. We have extended these studies to evaluating effects of ovarian steroid hormones on endothelial function. The work is performed at the cellular, molecular, and pre-clinical animal model levels.

Publications

Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR: Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arterioscler Thromb Vasc Biol. 2017 Feb; 2016 Nov 10. PMID: 27834690

Usselman CW, Stachenfeld NS, Bender JR: The molecular actions of oestrogen in the regulation of vascular health. Exp Physiol. 2016 Mar. PMID: 26778523

Nkonde-Price C, Bender JR: Menopause and the Heart. Endocrinol Metab Clin North Am. 2015 Sep; 2015 Jun 22. PMID: 26316243

Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R: The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. J Cell Sci. 2014 Oct 15; 2014 Sep 1. PMID: 25179599

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR: Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062

Kim KH, Young BD, Bender JR: Endothelial estrogen receptor isoforms and cardiovascular disease. Mol Cell Endocrinol. 2014 May 25; 2014 Feb 11. PMID: 24530925

Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR: Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. Am J Pathol. 2014 May; 2014 Mar 5. PMID: 24606881

Chau KH, Bender JR, Elefteriades JA: Silver lining in the dark cloud of aneurysm disease. Cardiology. 2014; 2014 Jun 17. PMID: 24942201

Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM: Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arterioscler Thromb Vasc Biol. 2012 Aug; 2012 Jun 21. PMID: 22723442

Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR: Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Am J Pathol. 2012 Apr; 2012 Feb 7. PMID: 22322302

Kim KH, Toomre D, Bender JR: Splice isoform estrogen receptors as integral transmembrane proteins. Mol Biol Cell. 2011 Nov; 2011 Sep 21. PMID: 21937726

Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR: T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade. PLoS One. 2010 Dec 29; 2010 Dec 29. PMID: 21206905

Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM: VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circ Res. 2010 Aug 6; 2010 Jun 10. PMID: 20538685

Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM: Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. J Biol Chem. 2009 Oct 23; 2009 Aug 19. PMID: 19696027

Kim KH, Bender JR: Membrane-initiated actions of estrogen on the endothelium. Mol Cell Endocrinol. 2009 Sep 24; 2009 Apr 9. PMID: 19549586

Kim KH, Moriarty K, Bender JR: Vascular cell signaling by membrane estrogen receptors. Steroids. 2008 Oct; 2008 Jan 18. PMID: 18325557

Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR: Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A. 2007 Oct 16; 2007 Oct 5. PMID: 17921256

Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER: ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. Am J Transplant. 2007 Sep. PMID: 17697260

Sadeghi MM, Bender JR: Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling. Trends Cardiovasc Med. 2007 Jan. PMID: 17210471

Moriarty K, Kim KH, Bender JR: Minireview: estrogen receptor-mediated rapid signaling. Endocrinology. 2006 Dec; 2006 Aug 31. PMID: 16946015

Wang JG, Collinge M, Ramgolam V, Ayalon O, Fan XC, Pardi R, Bender JR: LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation. J Immunol. 2006 Feb 15. PMID: 16455966

Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM: Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB J. 2005 Nov; 2005 Sep 8. PMID: 16150802

Mehra VC, Ramgolam VS, Bender JR: Cytokines and cardiovascular disease. J Leukoc Biol. 2005 Oct; 2005 Jul 8. PMID: 16006537

Kim KH, Bender JR: Rapid, estrogen receptor-mediated signaling: why is the endothelium so special? Sci STKE. 2005 Jun 14; 2005 Jun 14. PMID: 15956360

Hisamoto K, Bender JR: Vascular cell signaling by membrane estrogen receptors. Steroids. 2005 May-Jun; 2005 Mar 16. PMID: 15862821

Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR: Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation. 2004 Jul 6; 2004 Jun 21. PMID: 15210600

Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR: Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplant Proc. 2004 Jun. PMID: 15251390

Li L, Haynes MP, Bender JR: Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc Natl Acad Sci U S A. 2003 Apr 15; 2003 Apr 7. PMID: 12682286

Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR: Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem. 2003 Jan 24; 2002 Nov 12. PMID: 12431978

Conte MS, VanMeter GA, Akst LM, Clemons T, Kashgarian M, Bender JR: Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit. Cardiovasc Res. 2002 Feb 1. PMID: 11827702

Haynes MP, Li L, Russell KS, Bender JR: Rapid vascular cell responses to estrogen and membrane receptors. Vascul Pharmacol. 2002 Feb. PMID: 12379956

Snyder EL, O'Donnell L, Dengler TJ, Pomper GJ, Velleca MA, Dincecco DM, Baril LL, Min K, Gudino MD, Bender JR: Ex vivo evaluation of PBMNCs collected with a new cell separator. Transfusion. 2001 Jul. PMID: 11452164

Sadeghi MM, Tiglio A, Sadigh K, O'Donnell L, Collinge M, Pardi R, Bender JR: Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation. 2001 May 15. PMID: 11397960

Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR: Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res. 2000 Oct 13. PMID: 11029403

Sadeghi MM, Collinge M, Pardi R, Bender JR: Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. J Immunol. 2000 Sep 1. PMID: 10946302

Haynes MP, Russell KS, Bender JR: Molecular mechanisms of estrogen actions on the vasculature. J Nucl Cardiol. 2000 Sep-Oct. PMID: 11083200

Russell KS, Haynes MP, Sinha D, Clerisme E, Bender JR: Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci U S A. 2000 May 23. PMID: 10823945

Liu YC, Pan J, Zhang C, Fan W, Collinge M, Bender JR, Weissman SM: A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc Natl Acad Sci U S A. 1999 Apr 13. PMID: 10200259

Cuff CA, Schwartz J, Bergman CM, Russell KS, Bender JR, Ruddle NH: Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development. J Immunol. 1998 Dec 15. PMID: 9862717

Collinge M, Pardi R, Bender JR: Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion. J Immunol. 1998 Aug 15. PMID: 9712019

Inaba M, Toninelli E, Vanmeter G, Bender JR, Conte MS: Retroviral gene transfer: effects on endothelial cell phenotype. J Surg Res. 1998 Jul 15. PMID: 9733614

Caulin-Glaser T, Farrell WJ, Pfau SE, Zaret B, Bunger K, Setaro JF, Brennan JJ, Bender JR, Cleman MW, Cabin HS, Remetz MS: Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. J Am Coll Cardiol. 1998 Jun. PMID: 9626834

Wang GJ, Collinge M, Blasi F, Pardi R, Bender JR: Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement. Proc Natl Acad Sci U S A. 1998 May 26. PMID: 9600959

Ayalon O, Hughes EA, Cresswell P, Lee J, O'Donnell L, Pardi R, Bender JR: Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis. Proc Natl Acad Sci U S A. 1998 Mar 3. PMID: 9482903

Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR: 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997 Nov. PMID: 9351464

Caulin-Glaser T, Watson CA, Pardi R, Bender JR: Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J Clin Invest. 1996 Jul 1. PMID: 8690801

Watson CA, Petzelbauer P, Zhou J, Pardi R, Bender JR: Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-gamma-dependent and -independent mechanisms. J Immunol. 1995 Apr 1. PMID: 7897208

Pfau S, Leitenberg D, Rinder H, Smith BR, Pardi R, Bender JR: Lymphocyte adhesion-dependent calcium signaling in human endothelial cells. J Cell Biol. 1995 Mar. PMID: 7533170

Milstone LM, Hough-Monroe L, Kugelman LC, Bender JR, Haggerty JG: Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion. J Cell Sci. 1994 Nov. PMID: 7699015

Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R: Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proc Natl Acad Sci U S A. 1994 Apr 26. PMID: 7513430

Jeffrey Bender

Jeffrey R. Bender, MD

Robert I. Levy Professor of Medicine (Cardiology) and Professor of Immunobiology

Contact Info
Academic Office
300 George Street
New Haven, CT 06511
Patient Care
Yale Cardiology
Yale New Haven Hospital
20 York Street
New Haven, CT 06510
Patient Care
Yale General Cardiology
Yale Physicians Building
800 Howard Avenue
New Haven, CT 06519