Hyung Joon Chun

Bio Profile

Hyung Chun, MD, FAHA

Associate Professor of Medicine (Cardiology)

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Chun Lab


We are interested in studying novel endothelial and vascular smooth muscle cell signaling pathways that are either disrupted or activated in the context of pulmonary arterial hypertension (PAH), a rare disease with high mortality (up to 45% at three years after diagnosis). We and others have shown that apelin-APJ signaling is disrupted in PAH patients and in experimental rodent models. Our ongoing studies are aimed at A) evaluating further downstream signaling mechanisms by which apelin mediates vascular homeostasis, B) role of microRNAs that are disrupted in PAH vasculature in the pathogenesis of disease, and C) identification and characterization of microRNA targeted signaling pathways such as FGF signaling as therapeutic targets.

Publications

Chun HJ, Bonnet S, Chan SY: Reply: Transforming Growth Factor β1- and Bone Morphogenetic Protein 2/PPARγ-regulated MicroRNAs in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2017 Nov 1. PMID: 28653904

Papangeli I, Chun HJ: A Tale of Two Elabela Null Mice. Trends Endocrinol Metab. 2017 Nov; 2017 Sep 27. PMID: 28964631

Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ: Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017 Sep 13. PMID: 28904225

Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L: Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med. 2017 Jun 15. PMID: 28430547

Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas JL, Bautch VL, Erzurum SC, Chun HJ, Jin SW: Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension. Circulation. 2017 Jun 6; 2017 Mar 29. PMID: 28356442

Lee A, Papangeli I, Park Y, Jeong HN, Choi J, Kang H, Jo HN, Kim J, Chun HJ: A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis. Sci Rep. 2017 May 31; 2017 May 31. PMID: 28566713

Bailey G, Healy A, Young BD, Sharma E, Meadows J, Chun HJ, Wu WC, Choudhary G, Morrison AR: Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium. PLoS One. 2017; 2017 Apr 24. PMID: 28437443

Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR: Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arterioscler Thromb Vasc Biol. 2017 Feb; 2016 Nov 10. PMID: 27834690

Chun HJ, Bonnet S, Chan SY: Translational Advances in the Field of Pulmonary Hypertension. Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than "miR" Words. Am J Respir Crit Care Med. 2017 Jan 15. PMID: 27648944

Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ: MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat Commun. 2016 Apr 12; 2016 Apr 12. PMID: 27068353

Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D: miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. Sci Rep. 2016 Feb 18; 2016 Feb 18. PMID: 26888314

Papangeli I, Sharma B, Chun HJ: Letter by Papangeli et al Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14. PMID: 26169651

Chun HJ, Yu PB: Elafin in pulmonary arterial hypertension. Beyond targeting elastases. Am J Respir Crit Care Med. 2015 Jun 1. PMID: 26029832

Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ: Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Circulation. 2015 Jan 13; 2014 Oct 21. PMID: 25336633

Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW: Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol. 2014 Feb; 2013 Dec 5. PMID: 24311379

Mehrotra D, Wu J, Papangeli I, Chun HJ: Endothelium as a gatekeeper of fatty acid transport. Trends Endocrinol Metab. 2014 Feb; 2013 Dec 3. PMID: 24315207

Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ: Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21; 2013 Apr 19. PMID: 23603510

Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA: Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Sleep Breath. 2013 Mar. PMID: 22294346

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ: An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013 Jan; 2012 Dec 23. PMID: 23263626

McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ: Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report. Arterioscler Thromb Vasc Biol. 2012 Nov; 2012 Sep 20. PMID: 22995518

Jane-Wit D, Chun HJ: Mechanisms of dysfunction in senescent pulmonary endothelium. J Gerontol A Biol Sci Med Sci. 2012 Mar; 2012 Mar 5. PMID: 22396472

Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ: Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2011 Apr; 2011 Jan 13. PMID: 21233449

Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM: MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol. 2011 Apr. PMID: 20857419

Kojima Y, Kundu RK, Cox CM, Leeper NJ, Anderson JA, Chun HJ, Ali ZA, Ashley EA, Krieg PA, Quertermous T: Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. Cardiovasc Res. 2010 Jul 1; 2010 Feb 22. PMID: 20176814

Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T: Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol. 2009 Nov; 2009 Sep 18. PMID: 19767528

Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC: Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol. 2009 Apr 7. PMID: 19341866

Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T: Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest. 2008 Oct. PMID: 18769630

Chun HJ, Narula J, Hofstra L, Wu JC: Intracellular and extracellular targets of molecular imaging in the myocardium. Nat Clin Pract Cardiovasc Med. 2008 Aug. PMID: 18641605

Chun HJ, Cook K, Wang PJ, Al-Ahmad A: Pacemaker alternans terminated by telemetry wand: what is the mechanism? Heart Rhythm. 2008 Jul; 2008 Mar 8. PMID: 18598969

Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T: In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Jan; 2007 Sep 28. PMID: 17906101

Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS: HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am J Physiol Endocrinol Metab. 2007 Dec; 2007 Sep 18. PMID: 17878221

Kutschka I, Sheikh AY, Sista R, Hendry SL, Chun HJ, Hoyt G, Kutschka W, Pelletier MP, Quertermous T, Wu JC, Robbins RC: A novel platform device for rodent echocardiography. ILAR J. 2007 Jun 6; 2007 Jun 6. PMID: 18506056

Chun HJ, Wilson KO, Huang M, Wu JC: Integration of genomics, proteomics, and imaging for cardiac stem cell therapy. Eur J Nucl Med Mol Imaging. 2007 Jun. PMID: 17464506

Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ: Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 2002 Sep 26. PMID: 12353035

Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ: Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A. 2001 Nov 20. PMID: 11717445

Chun HJ, Lenardo MJ: Autoimmune lymphoproliferative syndrome: types I, II and beyond. Adv Exp Med Biol. 2001. PMID: 11505974

Siegel RM, Chan FK, Chun HJ, Lenardo MJ: The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol. 2000 Dec. PMID: 11101867

Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ: A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000 Jun 30. PMID: 10875917

Chun HJ, Doty JR, Salazar JD, Richmond J, Fonger JD: Noninvasive graft flow and patency assessment following minimally invasive direct coronary artery bypass (MIDCAB) grafting. Heart Surg Forum. 1999. PMID: 11276481

Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH: NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science. 1996 Dec 13. PMID: 8943202