Daniel Goldstein

Bio Profile

Daniel Goldstein, MBBS

Director, Center for the Biology of Aging and Cardiovascular Diseases

Research Interests

Aging; Cardiology; Immune System; Immunity; Inflammation; Organ Transplantation; Transplantation

Clinical Interests

Cardiovascular Diseases; Heart Failure

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Goldstein Lab


The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging.

Publications

Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR: Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. J Immunol. 2017 Aug 1; 2017 Jun 23. PMID: 28646038

Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR: Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017 Jun; 2017 Mar 7. PMID: 28266167

Mori DN, Shen H, Galan A, Goldstein DR: Aged B cells alter immune regulation of allografts in mice. Eur J Immunol. 2016 Nov; 2016 Sep 21. PMID: 27546296

Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR: Age-associated vascular inflammation promotes monocytosis during atherogenesis. Aging Cell. 2016 Aug; 2016 May 2. PMID: 27135421

Jane-Wit D, Fang C, Goldstein DR: Innate immune mechanisms in transplant allograft vasculopathy. Curr Opin Organ Transplant. 2016 Jun. PMID: 27077602

Braza F, Brouard S, Chadban S, Goldstein DR: Role of TLRs and DAMPs in allograft inflammation and transplant outcomes. Nat Rev Nephrol. 2016 May; 2016 Mar 30. PMID: 27026348

Shen H, Heuzey E, Mori DN, Wong CK, Colangelo CM, Chung LM, Bruce C, Slizovskiy IB, Booth CJ, Kreisel D, Goldstein DR: Haptoglobin enhances cardiac transplant rejection. Circ Res. 2015 May 8; 2015 Mar 23. PMID: 25801896

Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D: DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation. J Immunol. 2015 Apr 15; 2015 Mar 11. PMID: 25762783

Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ: The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res. 2014 Jul; 2014 Mar 31. PMID: 24801837

Mori DN, Kreisel D, Fullerton JN, Gilroy DW, Goldstein DR: Inflammatory triggers of acute rejection of organ allografts. Immunol Rev. 2014 Mar. PMID: 24517430

Shaw AC, Goldstein DR, Montgomery RR: Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013 Dec; 2013 Oct 25. PMID: 24157572

Song Y, Shen H, Du W, Goldstein DR: Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages. Aging Cell. 2013 Oct; 2013 Jul 7. PMID: 23711292

Shen H, Kreisel D, Goldstein DR: Processes of sterile inflammation. J Immunol. 2013 Sep 15. PMID: 24014880

Wong C, Goldstein DR: Impact of aging on antigen presentation cell function of dendritic cells. Curr Opin Immunol. 2013 Aug; 2013 Jun 24. PMID: 23806201

Walker WE, Bozzi AT, Goldstein DR: IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model. J Leukoc Biol. 2012 Dec; 2012 Oct 9. PMID: 23048204

Goldstein DR: Role of aging on innate responses to viral infections. J Gerontol A Biol Sci Med Sci. 2012 Mar; 2011 Oct 31. PMID: 22042722

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR: Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2012 Jan; 2011 Oct 27. PMID: 22034510

Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR: Haptoglobin activates innate immunity to enhance acute transplant rejection in mice. J Clin Invest. 2012 Jan; 2011 Dec 12. PMID: 22156194

Shirali AC, Look M, Du W, Kassis E, Stout-Delgado HW, Fahmy TM, Goldstein DR: Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival. Am J Transplant. 2011 Dec; 2011 Aug 30. PMID: 21883921

Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR: Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection. Vaccine. 2011 Oct 19; 2011 Aug 18. PMID: 21854824

Du W, Shen H, Galan A, Goldstein DR: An age-specific CD8+ T cell pathway that impairs the effectiveness of strategies to prolong allograft survival. J Immunol. 2011 Oct 1; 2011 Aug 26. PMID: 21873523

Goldstein DR: T cell costimulation blockade and organ transplantation: a change of philosophy for transplant immunologists? J Immunol. 2011 Mar 1. PMID: 21325217

Goldstein DR: Inflammation and transplantation tolerance. Semin Immunopathol. 2011 Mar; 2011 Feb 18. PMID: 21331502

Leng J, Goldstein DR: Impact of aging on viral infections. Microbes Infect. 2010 Dec; 2010 Sep 16. PMID: 20849976

Goldstein DR: Aging, imbalanced inflammation and viral infection. Virulence. 2010 Jul-Aug. PMID: 21178458

Walker WE, Booth CJ, Goldstein DR: TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA. Mol Ther. 2010 Apr; 2010 Feb 9. PMID: 20145605

Stout-Delgado HW, Du W, Shirali AC, Booth CJ, Goldstein DR: Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe. 2009 Nov 19. PMID: 19917499

Walker WE, Goldstein DR: B cells are dispensable for neonatal transplant tolerance induction. Transplantation. 2009 Oct 15. PMID: 19935457

Shen H, Goldstein DR: IL-6 and TNF-alpha synergistically inhibit allograft acceptance. J Am Soc Nephrol. 2009 May; 2009 Apr 8. PMID: 19357252

Tesar BM, Du W, Shirali AC, Walker WE, Shen H, Goldstein DR: Aging augments IL-17 T-cell alloimmune responses. Am J Transplant. 2009 Jan; 2008 Oct 31. PMID: 18976294

Shen H, Tesar BM, Du W, Goldstein DR: Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation. PLoS One. 2009; 2009 Jan 1. PMID: 19119314

Stout-Delgado HW, Yang X, Walker WE, Tesar BM, Goldstein DR: Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol. 2008 Nov 15. PMID: 18981092

Shirali AC, Goldstein DR: Tracking the toll of kidney disease. J Am Soc Nephrol. 2008 Aug; 2008 Jun 25. PMID: 18579638

Shen H, Tesar BM, Walker WE, Goldstein DR: Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation. J Immunol. 2008 Aug 1. PMID: 18641322

Shirali AC, Goldstein DR: Activation of the innate immune system by the endogenous ligand hyaluronan. Curr Opin Organ Transplant. 2008 Feb. PMID: 18660702

Griffith JW, O'Connor C, Bernard K, Town T, Goldstein DR, Bucala R: Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis. 2007 Nov 15; 2007 Oct 31. PMID: 18008236

Walker WE, Goldstein DR: Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol. 2007 Aug 1. PMID: 17641036

Goldstein DR: The identity of innate immune activators in organ transplantation: origins from within or exterior to the host? Am J Transplant. 2007 Jul; 2007 May 25. PMID: 17524077

Tesar BM, Goldstein DR: Acute allograft rejection occurs independently of inducible heat shock protein-70. Transplantation. 2007 Jun 15. PMID: 17565327

Tesar BM, Goldstein DR: Toll-like receptors and their role in transplantation. Front Biosci. 2007 May 1; 2007 May 1. PMID: 17485369

Shen H, Goldstein DR: Role of Toll-like receptors in transplantation tolerance. Expert Rev Clin Immunol. 2007 Mar. PMID: 20477103

Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR: Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006 Dec. PMID: 17129212

Goldstein DR: Toll like receptors and acute allograft rejection. Transpl Immunol. 2006 Dec; 2006 Oct 10. PMID: 17157206

Tesar BM, Jiang D, Liang J, Palmer SM, Noble PW, Goldstein DR: The role of hyaluronan degradation products as innate alloimmune agonists. Am J Transplant. 2006 Nov. PMID: 17049055

Walker WE, Nasr IW, Camirand G, Tesar BM, Booth CJ, Goldstein DR: Absence of innate MyD88 signaling promotes inducible allograft acceptance. J Immunol. 2006 Oct 15. PMID: 17015716

Obhrai J, Goldstein DR: The role of toll-like receptors in solid organ transplantation. Transplantation. 2006 Feb 27. PMID: 16495791

Askenase PW, Itakura A, Leite-de-Moraes MC, Lisbonne M, Roongapinun S, Goldstein DR, Szczepanik M: TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol. 2005 Nov 15. PMID: 16272291

Goldstein DR, Palmer SM: Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. J Heart Lung Transplant. 2005 Nov. PMID: 16297771

Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov; 2005 Oct 23. PMID: 16244651

Goldstein DR: Toll-like receptors and other links between innate and acquired alloimmunity. Curr Opin Immunol. 2004 Oct. PMID: 15341996

Tesar BM, Chalasani G, Smith-Diggs L, Baddoura FK, Lakkis FG, Goldstein DR: Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs. J Immunol. 2004 Oct 1. PMID: 15383567

Tesar BM, Zhang J, Li Q, Goldstein DR: TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant. 2004 Sep. PMID: 15307830

Goldstein DR, Tesar BM, Akira S, Lakkis FG: Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest. 2003 May. PMID: 12750407

Goldstein DR, Coffey CS, Benza RL, Nanda NC, Bourge RC: Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantation. Am J Transplant. 2003 Apr. PMID: 12694073