Kathleen Martin

Bio Profile

Kathleen A Martin, PhD

Associate Professor of Medicine (Cardiology) and of Pharmacology

Associate Professor of Pharmacology

Research Interests

Cardiology; Cardiovascular Diseases; Pharmacology; Signal Transduction; Vascular Diseases

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Martin Lab


Our studies in the Martin Lab are aimed at understanding the molecular mechanisms that regulate vascular smooth muscle cell (VSMC) phenotype. Mature SMC retain the ability to de-differentiate and re-enter the cell cycle. This is essential for such processes as angiogenesis, but also contributes to the pathogenesis of intimal hyperplasia. Intimal hyperplasia is a complication that contributes to the failure of angioplasty, stenting, and bypass surgery via restenosis, as well as long term failure of heart transplants due to diffuse graft arteriosclerosis.

Publications

Martin KA, Mani MV, Mani A: New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol. 2015 Sep 15; 2015 May 19. PMID: 26001373

Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J: Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood. 2015 May 28; 2015 Mar 26. PMID: 25814526

Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA: Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal. 2015 May 12; 2015 May 12. PMID: 25969542

Liu R, Leslie KL, Martin KA: Epigenetic regulation of smooth muscle cell plasticity. Biochim Biophys Acta. 2015 Apr; 2014 Jun 15. PMID: 24937434

Martin KA, Hirschi KK: The magic touch: endothelial cells muscle-up adipose. Circ Res. 2014 Oct 10. PMID: 25301822

Liu R, Jin Y, Tang W, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA: Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity". Circulation. 2014 Aug 19. PMID: 25135133

Tang WH, Stitham J, Jin Y, Liu R, Lee SH, Du J, Atteya G, Gleim S, Spollett G, Martin K, Hwa J: Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation. 2014 Apr 15; 2014 Jan 28. PMID: 24474649

Thompson AM, Martin KA, Rzucidlo EM: Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK. PLoS One. 2014; 2014 Jan 8. PMID: 24416418

Guzman AK, Ding M, Xie Y, Martin KA: Pharmacogenetics of obesity drug therapy. Curr Mol Med. 2014. PMID: 25109792

Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA: Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 2013 Oct 29; 2013 Sep 27. PMID: 24077167

Gleim S, Stitham J, Tang WH, Li H, Douville K, Chelikani P, Rade JJ, Martin KA, Hwa J: Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis. PLoS One. 2013; 2013 Jun 28. PMID: 23840660

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr. PMID: 23454748

Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y: Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687

Gleim S, Stitham J, Tang WH, Martin KA, Hwa J: An eicosanoid-centric view of atherothrombotic risk factors. Cell Mol Life Sci. 2012 Oct; 2012 Apr 11. PMID: 22491820

Tang WH, Martin KA, Hwa J: Aldose reductase, oxidative stress, and diabetic mellitus. Front Pharmacol. 2012; 2012 May 9. PMID: 22582044

Ding M, CarrĂ£o AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA: Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol. 2012 Feb; 2011 Sep 17. PMID: 21952104

Ding M, Rzucidlo EM, Davey JC, Xie Y, Liu R, Jin Y, Stavola L, Martin KA: Adiponectin in the heart and vascular system. Vitam Horm. 2012. PMID: 23017720

Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J: Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. J Clin Invest. 2011 Nov; 2011 Oct 17. PMID: 22005299

Ding M, Xie Y, Wagner RJ, Jin Y, Carrao AC, Liu LS, Guzman AK, Powell RJ, Hwa J, Rzucidlo EM, Martin KA: Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4. Arterioscler Thromb Vasc Biol. 2011 Jun; 2011 Mar 31. PMID: 21454807

Stitham J, Midgett C, Martin KA, Hwa J: Prostacyclin: an inflammatory paradox. Front Pharmacol. 2011; 2011 May 13. PMID: 21687516

Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J: Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction. J Biol Chem. 2011 Mar 4; 2010 Dec 28. PMID: 21189259

Wagner RJ, Martin KA, Powell RJ, Rzucidlo EM: Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR. Am J Physiol Cell Physiol. 2010 Jul; 2010 Apr 7. PMID: 20375271

Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ: Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res. 2010 Mar 1; 2010 Feb 23. PMID: 20179202

Kasza Z, Fetalvero KM, Ding M, Wagner RJ, Acs K, Guzman AK, Douville KL, Powell RJ, Hwa J, Martin KA: Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation. J Mol Cell Cardiol. 2009 May; 2009 Jan 23. PMID: 19302827

Martin KA, Gleim S, Elderon L, Fetalvero K, Hwa J: The human prostacyclin receptor from structure function to disease. Prog Mol Biol Transl Sci. 2009; 2009 Oct 7. PMID: 20374736

Fetalvero KM, Zhang P, Shyu M, Young BT, Hwa J, Young RC, Martin KA: Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition. J Clin Invest. 2008 Dec; 2008 Nov 20. PMID: 19033666

Martin KA, Hwa J: Shp shape: FAKs about hypertrophy. Circ Res. 2008 Oct 10. PMID: 18845815

Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M: Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell. 2008 Oct 10. PMID: 18851840

Arehart E, Stitham J, Asselbergs FW, Douville K, MacKenzie T, Fetalvero KM, Gleim S, Kasza Z, Rao Y, Martel L, Segel S, Robb J, Kaplan A, Simons M, Powell RJ, Moore JH, Rimm EB, Martin KA, Hwa J: Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res. 2008 Apr 25; 2008 Mar 6. PMID: 18323528