Stefania Nicoli

Bio Profile

Stefania Nicoli, PhD

Assistant Professor of Medicine (Cardiology)

Research Interests

Blood-Brain Barrier; Cardiovascular System; MicroRNAs; Neurons; Zebrafish

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Nicoli Lab


The Nicoli Lab has three projects:

  1. Identification and regulation of miRNAs-mRNA during the development of zebrafish embryonic and adult vascular system;
  2. Generation of endothelial miRNAs mutant; and
  3. Role of miRNAs-mRNAs during artery–vein differentiation and function.
The lab takes advantage of the zebrafish as a model system to overcome these barriers. Our goal is to elucidate how miRNAs participated in the genetic network driving arteries-veins differentiation, angiogenesis, neuro-vascular and lymphatic development.

Publications

Kasper DM, Moro A, Ristori E, Narayanan A, Hill-Teran G, Fleming E, Moreno-Mateos M, Vejnar CE, Zhang J, Lee D, Gu M, Gerstein M, Giraldez A, Nicoli S: MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos. Dev Cell. 2017 Mar 27. PMID: 28350988

Narayanan A, Hill-Teran G, Moro A, Ristori E, Kasper DM, A Roden C, Lu J, Nicoli S: In vivo mutagenesis of miRNA gene families using a scalable multiplexed CRISPR/Cas9 nuclease system. Sci Rep. 2016 Aug 30; 2016 Aug 30. PMID: 27572667

Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S: Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. J Vis Exp. 2016 Feb 29; 2016 Feb 29. PMID: 26967835

Fortuna V, Pardanaud L, Brunet I, Ola R, Ristori E, Santoro MM, Nicoli S, Eichmann A: Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Rep. 2015 Jun 23; 2015 Jun 11. PMID: 26074079

Kallakuri S, Yu JA, Li J, Li Y, Weinstein BM, Nicoli S, Sun Z: Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol. 2015 Apr; 2014 Sep 11. PMID: 25214579

Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, Thomas JL, Nicoli S: A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Dev Cell. 2015 Mar 9; 2015 Feb 5. PMID: 25662174

Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA: Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. Elife. 2015 Feb 2; 2015 Feb 2. PMID: 25643397

Ristori E, Nicoli S: miRNAs expression profile in zebrafish developing vessels. Methods Mol Biol. 2015. PMID: 25468601

Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND: A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013 Apr; 2013 Mar 5. PMID: 23462469

Tobia C, Chiodelli P, Nicoli S, Dell'era P, Buraschi S, Mitola S, Foglia E, van Loenen PB, Alewijnse AE, Presta M: Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish. Arterioscler Thromb Vasc Biol. 2012 Sep; 2012 Jul 26. PMID: 22837470

Rissone A, Foglia E, Sangiorgio L, Cermenati S, Nicoli S, Cimbro S, Beltrame M, Bussolino F, Cotelli F, Arese M: The synaptic proteins β-neurexin and neuroligin synergize with extracellular matrix-binding vascular endothelial growth factor a during zebrafish vascular development. Arterioscler Thromb Vasc Biol. 2012 Jul; 2012 Apr 19. PMID: 22516065

Nicoli S, Knyphausen CP, Zhu LJ, Lakshmanan A, Lawson ND: miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell. 2012 Feb 14. PMID: 22340502

Zizioli D, Forlanelli E, Guarienti M, Nicoli S, Fanzani A, Bresciani R, Borsani G, Preti A, Cotelli F, Schu P: Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio). Dev Dyn. 2010 Sep. PMID: 20652956

Leali D, Bianchi R, Bugatti A, Nicoli S, Mitola S, Ragona L, Tomaselli S, Gallo G, Catello S, Rivieccio V, Zetta L, Presta M: Fibroblast growth factor 2-antagonist activity of a long-pentraxin 3-derived anti-angiogenic pentapeptide. J Cell Mol Med. 2010 Aug; 2010 Jul 20. PMID: 19627396

Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND: MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010 Apr 22; 2010 Apr 4. PMID: 20364122

Urbinati C, Nicoli S, Giacca M, David G, Fiorentini S, Caruso A, Alfano M, Cassetta L, Presta M, Rusnati M: HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium. Blood. 2009 Oct 8; 2009 Aug 6. PMID: 19661268

Nicoli S, De Sena G, Presta M: Fibroblast growth factor 2-induced angiogenesis in zebrafish: the zebrafish yolk membrane (ZFYM) angiogenesis assay. J Cell Mol Med. 2009 Aug; 2008 Jul 24. PMID: 18657228

Nicoli S, Tobia C, Gualandi L, De Sena G, Presta M: Calcitonin receptor-like receptor guides arterial differentiation in zebrafish. Blood. 2008 May 15; 2008 Mar 7. PMID: 18326814

Nicoli S, Ribatti D, Cotelli F, Presta M: Mammalian tumor xenografts induce neovascularization in zebrafish embryos. Cancer Res. 2007 Apr 1. PMID: 17409396

Nicoli S, Presta M: The zebrafish/tumor xenograft angiogenesis assay. Nat Protoc. 2007. PMID: 18007628

Belleri M, Ribatti D, Nicoli S, Cotelli F, Forti L, Vannini V, Stivala LA, Presta M: Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol Pharmacol. 2005 May; 2005 Feb 9. PMID: 15703378

Nicoli S, Gilardelli CN, Pozzoli O, Presta M, Cotelli F: Regulated expression pattern of gremlin during zebrafish development. Gene Expr Patterns. 2005 Apr; 2004 Dec 15. PMID: 15749084

Stefania Nicoli

Stefania Nicoli, PhD

Assistant Professor of Medicine (Cardiology)

Contact Info
Lab
Nicoli Lab
300 George Street
New Haven, CT 06511
Academic Office
300 George Street
New Haven, CT 06511