Mehran Sadeghi

Bio Profile

Mehran M Sadeghi, MD

Professor

Research Interests

Analytical, Diagnostic and Therapeutic Techniques and Equipment; Aneurysm; Aortic Diseases; Biomedical Technology; Cardiovascular Diseases; Diagnostic Techniques and Procedures; Diseases; Early Diagnosis; Health Care; Heart Diseases; Industry; Peripheral Vascular Diseases; Technology; Vascular Diseases

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Sadeghi Lab


The ultimate goal of research in our Cardiovascular Molecular Imaging Laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation.



Publications

Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R: Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017 Aug 10; 2017 Aug 10. PMID: 28798141

Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM: Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm. J Nucl Med. 2017 Aug; 2017 Mar 30. PMID: 28360209

Malm BJ, Sadeghi MM: Multi-modality molecular imaging of aortic aneurysms. J Nucl Cardiol. 2017 Apr 26; 2017 Apr 26. PMID: 28447279

Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R: Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology. 2017 Apr; 2016 Nov 16. PMID: 27849433

Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR: Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arterioscler Thromb Vasc Biol. 2017 Feb; 2016 Nov 10. PMID: 27834690

Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM: Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. J Nucl Med. 2017 Jan; 2016 Jul 28. PMID: 27469361

Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM: Optical imaging of MMP-12 active form in inflammation and aneurysm. Sci Rep. 2016 Dec 5; 2016 Dec 5. PMID: 27917892

Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L: Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjug Chem. 2016 Oct 19; 2016 Sep 14. PMID: 27564088

Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM: Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Sci Rep. 2016 Sep 13; 2016 Sep 13. PMID: 27619752

Miri R, Sajjadieh A, Parsamahjoob M, Hajibaratali B, Shekarchizadeh M, Kolahi AA, Sadeghi M, Ahmadi Z, Farmanara H, Shekarchizadeh-Esfahani M: Relationship between metabolic syndrome and angiographic severity of coronary artery disease. ARYA Atheroscler. 2016 Sep. PMID: 28458696

Golestani R, Jung JJ, Sadeghi MM: Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. J Clin Med. 2016 Jun 6; 2016 Jun 6. PMID: 27275836

Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM: The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. Am J Physiol Heart Circ Physiol. 2016 May 1; 2016 Feb 26. PMID: 26921437

Toczek J, Sadeghi MM: A New Tracer for Imaging Atherosclerosis. Circ Cardiovasc Imaging. 2016 May. PMID: 27162132

Toczek J, Sadeghi MM: Molecular imaging concepts. J Nucl Cardiol. 2016 Apr; 2016 Jan 25. PMID: 26809440

Sadeghi MM: Molecular cardiovascular imaging is ready for prime time: almost there. J Nucl Cardiol. 2016 Feb; 2015 Nov 5. PMID: 26542993

Toczek J, Meadows JL, Sadeghi MM: Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circ Cardiovasc Imaging. 2016 Jan. PMID: 26763279

Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G: Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients. Circ Res. 2015 Nov 6; 2015 Sep 23. PMID: 26399469

Sadeghi MM, Wu JC: Cardiovascular molecular imaging: Expanding the paradigms and parameters. J Nucl Cardiol. 2015 Jun; 2015 Mar 26. PMID: 25809082

Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM: Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. J Nucl Med. 2015 Jun; 2015 Apr 23. PMID: 25908827

Sadeghi MM: (18)F-FDG PET and vascular inflammation: time to refine the paradigm? J Nucl Cardiol. 2015 Apr. PMID: 24925623

Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM: Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circ Cardiovasc Imaging. 2015 Jan; 2014 Dec 30. PMID: 25550400

Tavakoli S, Vashist A, Sadeghi MM: Molecular imaging of plaque vulnerability. J Nucl Cardiol. 2014 Dec; 2014 Aug 15. PMID: 25124827

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E: Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 2014 Sep 4. PMID: 25189570

Golestani R, Sadeghi MM: Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management. J Nucl Cardiol. 2014 Apr; 2014 Jan 1. PMID: 24381115

Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM: Lipid lowering and imaging protease activation in atherosclerosis. J Nucl Cardiol. 2014 Apr; 2013 Dec 25. PMID: 24368425

Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec; 2013 Nov 1. PMID: 24177422

Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM: Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arterioscler Thromb Vasc Biol. 2012 Aug; 2012 Jun 21. PMID: 22723442

Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J: Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology. 2012 Apr; 2011 Dec 23. PMID: 22197438

Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM: Integrin-targeted imaging of inflammation in vascular remodeling. Arterioscler Thromb Vasc Biol. 2011 Dec; 2011 Sep 22. PMID: 21940943

Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM: Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. J Nucl Med. 2011 Nov; 2011 Oct 3. PMID: 21969358

Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM: Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arterioscler Thromb Vasc Biol. 2011 Jan; 2010 Oct 14. PMID: 20947820

Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM: VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circ Res. 2010 Aug 6; 2010 Jun 10. PMID: 20538685

Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM: Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med. 2010 Jul; 2010 Jun 16. PMID: 20554725

Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL: Imaging atherosclerosis and vulnerable plaque. J Nucl Med. 2010 May 1; 2010 Apr 15. PMID: 20395341

Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM: Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. J Biol Chem. 2009 Oct 23; 2009 Aug 19. PMID: 19696027

Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ: Multimodality cardiovascular molecular imaging, Part II. Circ Cardiovasc Imaging. 2009 Jan. PMID: 19808565

Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM: Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation. 2008 Nov 4; 2008 Oct 20. PMID: 18936327

Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ: Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. J Appl Physiol (1985). 2008 May; 2008 Mar 20. PMID: 18356482

Sadeghi MM, Bender JR: Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling. Trends Cardiovasc Med. 2007 Jan. PMID: 17210471

Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR: HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol. 2006 Nov; 2006 Jun 13. PMID: 16774905

Sadeghi MM: The pathobiology of the vessel wall: implications for imaging. J Nucl Cardiol. 2006 May-Jun. PMID: 16750785

Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR: HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J. 2005 Nov; 2005 Sep 13. PMID: 16160062

Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM: Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB J. 2005 Nov; 2005 Sep 8. PMID: 16150802

Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q: Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. J Biomed Opt. 2005 Jul-Aug. PMID: 16178644

Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ: Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation. 2005 Jun 21; 2005 Jun 13. PMID: 15956134

Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR: Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation. 2004 Jul 6; 2004 Jun 21. PMID: 15210600

Zeng L, Xu H, Chew TL, Chisholm R, Sadeghi MM, Kanwar YS, Danesh FR: Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. J Am Soc Nephrol. 2004 Jul. PMID: 15213258

Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ: Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004 Jun. PMID: 15199403

Zhu Q, Piao D, Sadeghi MM, Sinusas AJ: Simultaneous optical coherence tomography imaging and beta particle detection. Opt Lett. 2003 Sep 15. PMID: 13677543

Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS: 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci U S A. 2002 Jun 11; 2002 Jun 4. PMID: 12048257

Mehran Sadeghi

Contact Info
Lab
300 George Street
New Haven, CT 06511
Academic Office
300 George Street
New Haven, CT 06511
Academic Office
VA Connecticut Healthcare
950 Campbell Avenue
West Haven, CT 06516
Patient Care
Cardiology
VA Connecticut Healthcare
950 Campbell Avenue
West Haven, CT 06516
Lab
Cardiovascular Molecular Imaging Laboratory
VA Connecticut Healthcare
950 Campbell Avenue
West Haven, CT 06516